The present work was aimed for development and evaluation of monolithic polymeric patch for transdermal delivery of ondansetron hydrochloride at therapeutic level and prediction of in vivo performance in human from the ex vivo data across porcine ear epidermis. The monolithic matrix patch containing ondansetron hydrochloride was prepared by solvent evaporation technique using ethylcellulose (EC) and poyvinylpyrolidone (PVP) in varying proportins. The prepared patch was subjected to various physicochemical evaluations with respect to drug content, moisture content, moisture uptake, thickness and folding endurance. The ex vivo permeation of ondansetron was investigated across porcine ear epidermis using Keshary-Chien glass diffusion cell. The films were uniform with respect to drug content, thickness and with low moisture content and moisture uptake capacity. The DSC analyses confirmed the stability of ondansetron in the polymeric film. The SEM and XRD analyses confirmed that the drug was uniformly distributed in amorphous state. The permeation of ondansetron seemed to follow zero order kinetic by diffusion mechanism. The patch formulation having polymeric composition of EC:PVP at 1:1 with 15% w/w of lemon oil as permeation enhancer produced desired transdermal target flux of ondansetron hydrochloride at 179.93 µg/cm2/h. An area of 3 cm2 of patch would be required to deliver ondansetron at 26.2 ng/ml in human by transdermal route.
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